NAD (nicotinamide adenine dinucleotide) is a coenzyme that naturally exists in every cell of your body. It plays a vital role in energy production, DNA repair, and cell signaling. As we age, NAD levels decline, and that’s why NAD therapy (often through IV infusions, oral supplements, or precursors like NMN or NR) has gained attention for anti-aging, wellness, and metabolic health.
Here’s a breakdown of what’s known:
Where NAD Seems Promising
- Cellular energy & mitochondria: NAD is crucial for turning nutrients into ATP (cellular energy). Some studies show that boosting NAD can improve mitochondrial function, which may help with fatigue and overall energy.
- Metabolic health: Early research suggests NAD precursors may improve insulin sensitivity and support weight management in certain cases.
- Brain health: Some small studies and animal models suggest NAD may protect against neurodegeneration and support cognitive function, though more human evidence is needed.
- Aging research: In lab studies, higher NAD levels are linked with better DNA repair and healthier cell function, sparking interest in longevity and anti-aging.
Where Evidence Is Limited
- Direct anti-aging effects in humans: While animal studies are strong, large, long-term human trials are still lacking.
- IV NAD infusions: These are popular in wellness clinics, but there’s not much high-quality clinical research proving that IV is more effective than oral precursors.
- Chronic disease treatment: There’s no definitive evidence that NAD therapies cure or significantly reverse conditions like Alzheimer’s, Parkinson’s, or heart disease—though research is ongoing.
Safety
- Oral NAD precursors (like NMN and NR) generally appear safe in studies at moderate doses.
- NAD IV therapy is usually considered safe when given by medical professionals, but side effects like nausea, headaches, and flushing can happen.
- Long-term safety isn’t fully understood yet.
✅ Bottom line: NAD is real and biologically important. Supplementing NAD levels (through NR, NMN, or possibly IV NAD) shows promise for energy, metabolism, and healthy aging, but the science in humans is still early.